Drug interaction


When taking medications, patients often do not think about whether they are completely safe for them. It is no secret that the combination of several different drugs can lead to very dangerous side effects. What preparations should not be combined and how to search for information on this topic?

Dangerous drug interactions
Taking several drugs at the same time increases the risk of their interaction. As a result, the body may be affected differently from what the manufacturer claims. The more drugs a patient takes, the greater the risk of adverse interactions between them. This problem especially affects the elderly, who are treated for several diseases at the same time and have to take dozens of pharmaceutical drugs at the same time. On the one hand, drugs can weaken or intensify each other’s effects. Concomitant use of some drugs may increase or decrease the therapeutic effect. In addition, the combination of several active substances can create a new, often toxic effect. Therefore, it is very important to take medication consciously.

What drugs should not be combined?
There are many combinations of medications that can prevent your benefit. One example is the combination of acetylsalicylic acid with ibuprofen. The first weakens the effect of ibuprofen and increases the side effects on the gastric mucosa. ibuprofen reduces the cardioprotective and anticoagulant effect of aspirin. Another dangerous example is the combination of non-steroidal anti-inflammatory drugs (ibuprofen, ketoprofen, naproxen) with paracetamol. Combination of these drugs can lead to kidney problems.

How to know which combination of drugs to avoid? Basically, of course, read the package insert. Unfortunately, some patients read the leaflets too superficially or miss this stage altogether. Therefore, it is advisable to use our database of interactions, so that we know what interactions occur between the active substances contained in the drugs used.